Our goal is to develop new conjugate compounds that combine the function and targeting ability of estrogenic and antiestrogenic drugs with additional functions from other types of molecules. Those molecules might be fluorescent tags, that could allow visualization of drug localization, or polymer chains that could restrict the distribution of the drug to certain tissues or cellular locations. You could also attach radioactive isotopes to these drugs that could be used for either diagnostic imaging of potentially responsive tumors or as therapeutics capable of killing those tumors. These “theranostics” could represent an entirely new method for treating breast cancer.<\/p>\n
The work on this project is a combination of synthetic chemistry (to make the conjugates), biochemistry (to test the activity of the conjugates in vitro and in cellular assays) and imaging (to see where the conjugates go).<\/p>\n","protected":false},"excerpt":{"rendered":"
Our goal is to develop new conjugate compounds that combine the function and targeting ability of estrogenic and antiestrogenic drugs with additional functions from other types of molecules. Those molecules might be fluorescent tags, that could allow visualization of drug localization, or polymer chains that could restrict the distribution of the drug to certain tissues or cellular locations. You could…<\/p>\n